
Doxylamine is a member of the ethanolamine class of antihistamines and is the second most powerful antihistamine available (after diphenhydramine, the main ingredient in Benadryl). Although second in allergy-fighting power, it is first in sedating power (amongst the OTC drugs), making it a popular choice for sleep medications.
When combined with vitamin B6, it is also used to treat morning-sickness in pregnant women.